Type of Antibody |
Molecular Weight,
(kD) |
Specificity of the antigens |
anti-AMA
(M2-Type)
Mitochondrial antibodies
are directed against proteins of
the inner and outer
membrane of the mitochondria and react with proteins of the a cetoacid
dehydrogenase complex of the mitochondria |
74 kD
50 kD, 54 kD
Other additional bands at 54 kD
and 52 kD are rather close to the LP- and LKM antigens. |
Highly
specific and highly sensitive marker for
primary
biliary cirrhosis (PBC),
a chronic cholestatic liver disease.
In M2-positive
samples the major band against the 74 kD Antigen must be present!! |
anti-LKM
The so-called
`liver-kidney-microsomal`
antibodies (anti-LKM)
are
directed against proteins of the cytochrom-P-450 system |
50 kD |
They are a
marker for
autoimmune
chronic active hepatitis.
These antibodies are specific
for a subgroup of the autoimmune hepatitis and are mainly detected in
younger patients, aging from childhood up to less than 30 years of age. |
anti-LP
These antibodies are directed
against a cytoplasmatic antigen |
51 kD |
Disease-specific
anti-LP
(liver-pancreas / anti-SLA) antibodies
are associated with
chronic active
hepatitis
and are found in approx. 25 percent of CAH-patients. |